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The mean absolute oral bioavailability is 41% (range 25-63%). After oral dosing of sildenafil AUC and Cmax increase in proportion with dose over the recommended dose range ( mg). No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. Cimetidine (800 mg), a cytochrome P450 inhibitor and non-specific CYP3A4 inhibitor, caused a 56% increase in plasma sildenafil concentrations when co-administered with sildenafil (50 mg) to healthy volunteers. Since sildenafil clearance is reduced in patients with hepatic impairment (e.g. cirrhosis) a 25 mg dose should be considered. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to 100 mg as necessary.

Sometimes a lower starting dose of 25mg will be suggested by a clinician. This route may be considered if you’re already taking certain medications for the treatment of kidney, liver or heart conditions. Or if your previous tolerance of sildenafil citrate 50mg was low.

Structurally vardenafil (Levitra Soft) is similar to sildenafil, while tadalafil (Cialis) is very different. Vardenafil (Levitra) is almost 10 times more biochemically potent than sildenafil, therefore a lower dose is needed to facilitate the penile erection, potentially resulting in less side effects. Selectivity is the ability of the drug to attach to the specific enzyme PDE 5 found in penile tissues. Vardenafil (Levitra) is more selective than sildenafil and tadalafil (Cialis) to PDE5, which again means a lower dose is needed with potentially less side effects. Tadalafil is very specific for PDE5 and is also very specific for the enzyme PDE11. Unfortunately, we don’t know much about PDE11, which is found in the heart, in the pituitary gland in the brain and in the testicles.

Thankfully, Felix is making it quick and seamless for Canadians to access sildenafil online. Just complete an online assessment, and if your practitioner believes it’s right for you, they can provide you with a sildenafil prescription. During your online visit you'll be asked for information about your health history for the doctor to review. Your Felix doctor will use this information to determine safety and potential side effects. Your healthcare practitioner will build a personalized plan just for you.

Taking more than a single prescribed dose in the same day increases your chance of priapism, or a permanent erection, and other serious side effects. The nine pounds of pills were seized for unlawful importation of mediation. The pills have an estimated manufacturer’s suggested retail price (MSRP) of approximately $96,608. As a general rule, the FDA does not allow the importation of prescription drugs that were purchased outside the United States.

At Menschem we provide a secure and discreet service at very competitive online prices for the treatment of erectile dysfunction. Erectile Dysfunction or Impotance is the inability to keep or get and erection firm enough to have sexual intercourse. The treatments we offer increase blood flow to the penis allowing you to maintain a firmer erection. When you are sexually aroused, blood vessels in the penis relax and widen, allowing for an influx of blood. Certain factors, such as your state of mind, physical health, or other external factors can reduce blood flow to the penis. Viagra is a drug which helps to increase blood flow to the penis, allowing you to achieve and maintain an erection.

It is used for the treatment of erectile dysfunction (male impotence). It helps to achieve and keep an erection sufficient for sexual activity. It does this by allowing a greater blood flow into the penis when a man is sexually aroused.

Some men will experience unwanted side effects even on the median dose of Viagra. This sort of problem can sometimes be resolved by moving to the lower dose. Your doctor will discuss making this change with you